منابع مشابه
Once daily slow-release hydralazine in hypertension.
Hydralazine has been used for the treatment of hypertension since 1950 (Gross et al., 1950), but only since the introduction of beta-adrenoceptor blocking agents has its use again become popular (Koch-Weser, 1976). Originally, hydralazine was given in four divided doses, but it has been shown to be equally effective and without increased side-effects when given by twice daily dosage (O'Malley e...
متن کاملOnce-daily metoprolol for hypertension.
Introduction One of the problems encountered in the treatment of hypertension is that the long duration of therapy coupled with multiple dosage regimens in asymptomatic patients lead to poor compliance (Sackett and Haynes, 1976). Once-daily treatment regimens with P-adrenoceptor blockers other than metoprolol have been shown to be effective (Wilcox, 1978; Watson, Stallard and Littler, 1980). It...
متن کاملA comparison of once and twice daily atenolol in hypertension.
The hypertensive action of atenolol has been studied in a randomized double-blind crossover comparison. Twelve patients showed a highly significant reduction in average supine systolic and diastolic blood pressures from pre-treatment values of 196.3/115.9 to 159.1/89.2 mmHg (26.1/15.4 kPa to 22.2/11.9 kPa) after 2 weeks on once daily atenolol. No dose-related reduction in blood pressure was see...
متن کاملOnce-daily fosinopril in the treatment of hypertension.
This multicenter, dose-ranging study evaluated the antihypertensive effectiveness of once-daily administration of fosinopril sodium in 220 patients with supine diastolic blood pressure of 95-115 mm Hg. After a 4-week placebo period, patients were randomly assigned to double-blind therapy with either placebo or 10, 40, or 80 mg fosinopril once daily for 4 weeks. If treatment goals were not met, ...
متن کاملOnce daily felodipine monotherapy in mild to moderate hypertension.
In a single-blind study conducted at our centres, 78 hypertensive patients were enrolled with 58 completing the study according to the protocol. Mean supine and standing blood pressures were significantly reduced after treatment with felodipine, reductions being 27/21 mmHg (p < 0.0001) and 25/19 mmHg (p < 0.0001) respectively. Of 46 patients given felodipine 5 mg, 44 (95.7%) achieved target blo...
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ژورنال
عنوان ژورنال: BMJ
سال: 1982
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.284.6329.1602